Resveratrol Is a Healthier Anti-Inflammatory Alternative to Glucocorticosteroids
Resveratrol and Inflammation
In addition to its other beneficial effects, resveratrol and resveratrol supplements have been found to cause anti-inflammatory actions in the body. These actions could potentially influence treatments of inflammatory diseases, including:
- chronic obstructive pulmonary disease (COPD)
- autoimmune disease
- the painful condition of arthritis
Let’s investigate the benefits of using resveratrol to combat inflammation over some of the popular medical solutions used today.
Researcher Louise Donnelly at the Imperial College in Londa studied that anti-inflammatory properties of resveratrol. With her team, she looked at the manner in which resveratrol affects human airway epithelial cells, which were obtained from normal lung cells in the lab.
The researchers found resveratrol to have novel anti-inflammatory properties that were not the result of steroid production or action. Without causing the body to synthesize steroids, resveratrol appears to have the same effect on cells as the glucocorticosteroids with which asthmatics and other suffers of autoimmune disease are familiar.
The Downside of Glucocorticosteroids
Glucocorticosteroids may be an effective treatment for many disease sufferers, but they have upsetting side effects.
Long-term use of glucocorticosteroids can can result in the following sides:
- inhibited bone formation
- decreased healing factors
- immune system suppression
- increased the risk of infection
- reported muscle weakness
- among other unpleasant effects…
Accordingly, other therapies that do not cause such serious side effects would be preferable for many patients.
Resveratrol as a Healthy Alternative
Interestingly enough, the research also revealed that resveratrol does not work by influencing the glucocorticoid or estrogen receptors.
Glucocorticoid medications work by binding their receptor and forming a complex that moves into the cell and then into the nucleus, where it alters the expression of certain genes. This process is often referred to as transactivation.
The cell then begins producing different proteins or different amounts of certain proteins.
Glucocorticoids also induce an opposite process. When they bind to a hormone receptor on the outside of a cell, they prevent the transcription of some genes and reduce the amount of pro-inflammatory proteins produced at the cellular level.
Since resveratrol works via another biological pathway, it could feasibly help in the treatment of diseases that do respond well to steroid treatment. Such diseases include steroid-resistant asthma and arthritis.
Additional research may elucidate the means by which resveratrol promote anti-inflammatory action.
A better understanding of its properties could make it possible for scientists to develop specific therapies based on resveratrol or in combination with other anti-inflammatory agents for patients with painful diseases or chronic autoimmune problems.
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